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U.K. Regulator Issues Drug Safety Update For Rasilez

British regulator, the Medicines and Healthcare products Regulatory Agency (MHRA), just issued a Drug Safety Update for Rasilez, sold as Tekturna in the United States

Using aliskiren (Rasilez or Tekturna) in combination with two types of heart drugs—angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor blockers (ARB)—has been linked to serious and adverse cardiovascular and renal reactions in a large clinical trial known as ALTITUDE, said NewsInferno. According to the MHRA, this combination is now contraindicated in Type 1 and Type 2 diabetics and for patients with kidney impairment. Also, said the MHRA, the aliskiren combination with an ACE inhibitor or an ARB, is not recommended for patients with severe renal impairment. (more…)

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