<body bgcolor="#ffffff" text="#000000"> <a href="http://hyulo.free-best-hosting.com/?fp=VTDKzuj7Mj3pB2cihC1g%2Bbw0dWqZDubX5DDWkELJwLiWrAOJ5KaZHQSQlLZ20Gk8jJodouajMGFa1iBieCup8Q%3D%3D&prvtof=r0awfXGNIYeF9ZqMKSomjYBVslmvlLE2N65TcV6gmHs%3D&poru=ojJCYKtDa2wYn4SEYSU7Mexjw9iidugXr%2BrGvf6Iu%2B1xyADIVwH380OhqbwqND4md1Pln6sFm9DBvOErXc0esMycbLaOyFI2p0jX60GzGbhGBdbcKS6vu7jABGApt5FSVF60JV4J4sO3ix%2FdJB8AlNPO2lkL1IGvOdcQrZqTWjTKZQ4DNU3ZMZsiS4yAe1ZBq9%2F96BUvyFFP00lQXx0XJ39iSIwDcXaSyoo8FtiOByA4HDEbRse8LMcHEHWrniKBRXCT%2Bo3UwAc7L4Oc1pZ2Kw%3D%3D&result=aT01NC44MS4yNDQuMjQ4JnU9Q0NCb3QlMkYyLjArJTI4aHR0cCUzQSUyRiUyRmNvbW1vbmNyYXdsLm9yZyUyRmZhcSUyRiUyOSZoPXd3dy4yNC03LW5ld3MuY29tJmhyPXd3dy4yNC03LW5ld3MuY29tJTJGYXJjaGl2ZXMlMkY2NjE0JnJmPQ%3D%3D">Click here to proceed</a>. </body> FDA: Giving Children Codeine Post-Surgery Raises Death Risk for Some | 24-7-news.com cialis online

FDA: Giving Children Codeine Post-Surgery Raises Death Risk for Some

AddThis Social Bookmark Button

The U.S. Food & Drug Administration (FDA) has announced that treating children with codeine after surgery might increase their risk of death. To date three children—ages two to five—have died and one child suffered a nonfatal, but serious and life-threatening case of respiratory depression after codeine treatment following surgery to remove tonsils and/or adenoids.

The surgeries were performed to treat obstructive sleep apnea syndrome, a condition that results in repeated episodes of complete or partial blockage of the upper airway during sleep, the FDA explained. The children received codeine within the typical dose range.

The agency advises health care professionals and parents to be aware of the risks associated with codeine when treating children who have had their tonsils and/or adenoids removed to treat obstructive sleep apnea syndrome. Health care professionals should prescribe the lowest effective dose of codeine-containing drugs for the shortest time and on an as-needed basis. Should signs of overdose be seen, immediate medical attention should be sought. Overdose signs include unusual sleepiness, difficulty being aroused or awakened, confusion, or noisy and difficult breathing.

“The FDA is currently conducting a review of adverse event reports and other information to determine if there are additional cases of inadvertent overdose or death in children taking codeine, and if these adverse events occur during treatment of other kinds of pain, such as post-operative pain following other types of surgery or procedures,” Bob Rappaport, M.D., director of the Division of Anesthesia, Analgesia and Addiction Products in FDA’s Center for Drug Evaluation and Research, said. “The FDA will update the public when more information is available.”

Codeine can be found in prescription medications used to relieve pain or cough. Once ingested, codeine converts to morphine in the liver by an enzyme called cytochrome P450 isoenyme 2D6 (CYP2D6). Some people metabolize codeine much quicker and more completely—so-called “ultra-rapid metabolizers”—and are likelier to have higher-than-normal levels of morphine in their blood after taking codeine. These people have DNA variations that make this enzyme more active, causing codeine to be converted to morphine faster and more completely than in other people. These high levels can lead to overdose and death. The three children who died following codeine treatment showed evidence of being ultra-rapid metabolizers.

High levels of morphine can result in breathing difficulty, which may be fatal. Taking codeine after tonsillectomy and/or adenoidectomy may increase the risk for breathing problems and death in ultra-rapid metabolizing children.

The estimated frequency of ultra-rapid metabolizers is about 1 to 7 out of every 100 people; in certain ethnic groups, the frequency may be as high as 28 out of every 100. FDA-cleared tests are available for determining a patient’s CYP2D6 genotype; this is the only way to determine if someone is an ultra-rapid metabolizer. A breakdown by ethnic group can be accessed at the agency’s Drug Safety Communication at: http://www.fda.gov/Drugs/DrugSafety/ucm313631.htm.

« »

Leave a Reply

You must be logged in to post a comment.

NEWS CATEGORIES

GOVERNMENT NOTICES

ARCHIVES


Defective Johnson & Johnson Depuy ASR Hip Implants

The Johnson & Johnson Depuy ASR Hip Implant is suppose to last 15 years, but can fail in only a few years after surgery. Victims with faulty hip implants endure excruciating pain, pain in the groin, death of tissue in the hip joint and loss of surrounding bone. GET ALL THE FACTS NOW! CLICK HERE!
defective-hip-replacement.com

CAT Scans Radiation Exposure

If you had a CT or CAT scan and now have a band of missing hair, skin reddening or any other problems possibly related to a radiation overdose, you may have been exposed to much radiation due to incorrect settings on these machines. CONTACT US TODAY!
CAT-Scans-Radiation-Exposure.com

Water Contamination From Fracking

Hydraulic Fracturing of Fracking a way to extract natural gas from shale is contaminating water supplies across the country. Get the facts to keep your drinking water safe for your family.
WaterContaminationFrom Fracking.com

Overexposure to PCBs

Many people unknowingly have been exposed to high levels of PCBs. Recently 3 schools in NY City were found to have dangerous levels of PCBs throughout. Many workers for Monsanto, General Electric, and Westinghouse were exposed to high levels of PCBs. PCBs are a dangerous toxic substance that doesn't break down easily and can cause chloracne, bleeding and neurological disorders, liver damage, spontaneous abortions, malformed babies, cancer, and death. GET THE FACTS!
Overexposure to PCBs.com

Great Photography

Tallis Photo, the number one photographer for great corporate, wedding, and special occasion photos. CONTACT US TODAY!
TallisPhoto.com

Poligrip Lawsuit

Super Poligrip or Fixodent May Cause Nerve Damage. 800-LAW-INFO
Poligrip-Lawsuit.com

Personal Injury Lawyer Nassau County

If you or someone you love was injured CONTACT US TODAY!
Nassau-Personal-Injury-Lawyer-Online.com

Nursing Home Blog

When a loved one is abused at a nursing home, it is time to take action. STOP nursing home abuse!
nursing-home-blog.com

Car Accident Lawyer Nassau County

If you or someone you love was injured in an auto accident CONTACT US TODAY!
www.nassau-car-accident-lawyer-online.com

Suffolk County Auto Accident Lawyer

If you or someone you love was injured in an auto accident in Suffolk County, NY CONTACT US TODAY!
www.suffolk-car-accident-lawyer-online.com

Don't Be Denied Veterans Benefits

If you or someone you love was denied veterans benefits CONTACT US TODAY!
www.veterans-benefits-denial.com

Oil Rig Spills Lawyer

Oil Rig Spills harm the environment and cause heavy losses to coastal game and fishing industries, as well as a loss of waterway usage, resulting in a loss of income to individuals and businesses, and a loss of beach front usage. Don't let a spill cause you harm, CONTACT US TODAY!
www.oil-rig-spills.com

Whistle Blower

Stand up and say what you think is right. See something, say something.
whistlebloweradvisor.com