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First-Time Bisphosphonate Users At Risk For Eye Diseases | 24-7-news.com cialis online

First-Time Bisphosphonate Users At Risk For Eye Diseases

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First-time bisphosphonate users are at increased risk for eye diseases, according to an emerging study. Fosamax and Actonel are two of the most popularly prescribed drugs in this class and are used in the treatment of osteoporosis.

The inflammatory eye diseases—anterior uveitis and sleritis—can lead to significant vision impairment, according to case reports, said Philly.com. The study appears in the April 2 issue of the journal Canadian Medical Association Journal (CMAJ). Uveitis is inflammation of the eye’s middle layer; rarely, this can lead to blindness. Scleritis is inflammation of the eye’s outer wall.

The Canadian researchers looked at some 11,000 first-time oral bisphosphonate users and over 920,000 nonusers and found that the first-time user group experienced incidence rates of 29 per 10,000 person-years for uveitis and 63 per 10,000 person-years for scleritis versus 20 and 26 each, respectively, per 10,000 in the nonuser groups, said Philly.com. A person-year is the number of participants multiplied by the number of years the drug is taken.

“We found that first-time users of bisphosphonates are at an increased risk of scleritis and uveitis,” wrote Dr. Mahyar Etminan, of the Child and Family Research Institute and the Department of Medicine at the University of British Columbia, and colleagues in a journal news release, said Philly.com. “Our study highlights the need for clinicians to inform their patients about the signs and symptoms of scleritis and uveitis, so that prompt treatment may be sought and further complications averted,” the authors added. NewsInferno pointed out that the authors explained the bisphosphonate eye disease risk does not appear in any of the drugs’ prescribing information.

Usually reversible if caught early, drug-induced inflammatory eye disease is treated with corticosteroids, and patients are advised to stop taking the bisphosphonates.

Fosamax and bisphosphonates are approved to treat bone disorders, including osteoporosis in post-menopausal women, and Paget’s disease. In addition to Fosamax and Actonel, other oral bisphosphonates of this type are Boniva, Didronel, and Skelid.

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