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NSAIDS Pose Miscarriage Risk

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An emerging study suggests that some common NSAIDs, such as ibuprofen and naproxen, could increase risks for miscarriage when taken in early pregnancy.
MSNBC reported that the miscarriage risk was more than doubled in women who took an NSAID (nonsteroidal anti-inflammatory drugs) during their first 20 weeks of pregnancy, based on a Canadian study involving the health records of nearly 50,000 women. The study appears in the current Canadian Medical Association Journal.

“I would strongly suggest that women take no non-steroidal anti-inflammatory drugs during the first trimester,” said study co-author Dr. Anick Bérard, a professor of epidemiology at the University of Montreal and director of the research unit on medications and pregnancy at Centre Hospitalier Universitaire Ste. Justine, reported MSNBC. “If a woman is taking an NSAID for a chronic condition she really has to talk to her health care provider to see if it’s feasible to stop at least during the first trimester,” Dr. Bérard added.

The study involved women from the age of 15 through 45 and records went back to the first day of gestation. The women had filled at least one prescription for an NSAID in their first 20 weeks of pregnancy or in the two weeks before becoming pregnant. In all, 4,705 cases of miscarriage up to the women’s 20th week of gestation were counted. Of those, 352 (7.5%) in women took nonaspirin NSAIDs.. Of the 47,050 women who did not suffer a miscarriage, 1213 (2.6%) were exposed to nonaspirin NSAIDs.

Because NSAIDs affect the levels of some hormone-like substances known as prostaglandins, the drugs could impact pregnancy, said the team. Prostaglandins naturally and consistently decrease in the uterus during pregnancy; however, NSAIDs could create an unexpected fluctuation, the researchers pointed out, reported MSNBC.

Some 30 million Americans take NSAIDs daily, and are among the drugs most often taken by pregnant women.

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