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PCI Patients Face Risks from Plavix, PPI Combo | cialis online

PCI Patients Face Risks from Plavix, PPI Combo

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A recent study says high-risk cardiovascular patients undergoing percutaneous coronary intervention (PCI), while using Plavix and proton pump inhibitors (PPIs) are at an increased risk of cardiac events. According to a report by HealthDay News, the study published online in the Journal of Internal Medicine on July 5, revealed that high-risk cardiovascular patients may need to avoid combining Plavix with PPIs to decrease their chances of suffering from various health complications, such as myocardial infarction (MI), other major adverse cardiac events and death. Physicians often prescribe the two drugs in combination to prevent clotting and to reduce the risk of stomach bleeding, which can be a serious complication for patients taking Plavix. Plavix is a blood thinning drug used to prevent blood clots, which can cause heart attacks or strokes in high-risk patients, says the FDA. Thilo Burkard, M.D., from the Cardiology University Hospital Basel in Switzerland, and colleagues studied the results of drug therapy using Plavix and PPIs

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to determine whether the combination increased the risk of cardiac events after patients underwent PCI. The study included 801 patients who had the surgery and were taking Plavix for six months. After the researchers added PPIs to the participants’ drug therapy, they found that 14 percent of patients taking the combination were at a greater risk of experiencing cardiac events, versus those who did not receive Plavix and PPIs. The rates of major adverse cardiac events (30.3 versus 20.8 percent) and MI (14.7 versus 7.4 percent) were significantly higher in patients receiving the combination therapy. Researchers concluded that, “In a real-world PCI population, the combination of PPIs and Plavix was associated with a doubling of MI rates after three years,” reported HealthDay News. In 2009, the U.S. Food and Drug Administration released a safety announcement saying reports suggested that use of Plavix combined with certain PPIs made the blood thinning drug less effective.

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