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Proton Pump Inhibitor Study Links Heartburn Drugs to Hypomagnesaemia, | cialis online

Proton Pump Inhibitor Study Links Heartburn Drugs to Hypomagnesaemia,

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A new study shows proton pump inhibitors are associated with hypomagnesaemia, says Internal Medicine News. Researchers presented the results at the annual Digestive Disease Week and reported that both high and low defined daily doses are linked to an increased risk of hypomagnesaemia, which indicates the effects of proton pump inhibitors (PPI) use on serum magnesium levels is not dose related.

The study involved 1,317 hospital patients at a rural community in southeast Ohio, of whom 464 were PPI users and the remaining were not. The PPI users and non-users were similar in age, gender, past smoking history, length of hospital stay and discharge diagnosis.

In logistic regression analysis, PPI therapy was associated with an increased risk of hypomagnesaemia occurrence and the risk remained significant even after factors such as age, sex and serum albumin levels were adjusted, said Dr. Jen-Tzer Gau, chair of geriatric medicine/gerontology at Ohio University College of Osteopathic Medicine in Athens.

A regression analysis revealed no significant association between PPI use and hypomagnesaemia in higher doses of PPIs in comparison to those who did not receive the therapy.

The study also showed patients with lower serum albumin levels experienced significantly lower magnesium levels and an increased risk of hypomagnesaemia, reported IMN.

Earlier this year, the U.S. Food and Drug Administration (FDA) issued a warning that long-term use of PPIs can reduce magnesium levels, tetany, arrhythmias and seizures. The agency based the alert on 38 cases in their Adverse Event Reporting System and 23 cases in medical literature. The FDA advised that physicians test patient magnesium levels before initiating PPI therapy and periodically check the levels throughout treatment.

The study results are limited due to most of the participants being Caucasian.

PPIs are often used to reduce acid reflux in the stomach. The drugs are also prescribed to prevent calcium absorption often associated with bone deterioration and eventual fractures.

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