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Actos Reports Indicate Possible Bladder Cancer Risk | cialis online

Actos Reports Indicate Possible Bladder Cancer Risk

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Reports reveal those taking the diabetes drug Actos are at higher risk of developing bladder cancer. Currently, the Actos Medication Guide states that a possible side effect of the drug is bladder cancer. The

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manufacturer claims there is a “small chance” of developing bladder cancer; however, statistical data is still being tested to determine patient risk. According to Reuters Health, between 2004 and 2009, more than half a million adverse reactions in patients taking anti-diabetic drugs were added in an official FDA database. There were 138 cases of bladder cancer where the patient was taking at least one of more than 15 anti-diabetes drugs, and more than a fifth of those patients were taking Actos. Study author, Dr. Elisbetta Poluzzi, stated these results only suggest a “disproportionate risk” in comparison to the other 15 anti-diabetes drugs. However, in 2010 the U.S. Food & Drug Administration (FDA) found this risk alarming enough to begin a safety review of the drug upon receiving study results from the drug’s manufacturer, Takeda Pharmaceutical Co. Ltd., which demonstrated an increased risk of bladder cancer in patients with extended exposure to the drug. Takeda is conducting a ten-year study involving 193,000 diabetes patients to evaluate the risk of bladder cancer in those taking Actos. At the five-mark, the data collected between January 1, 1997 and April 20, 2008, lacked significant association between exposure to Actos and bladder cancer. Despite the statistical data, the FDA concluded the risk of bladder cancer increased in patients taking a high dosage of the drug and became significant after 24 months. Actos, known generically as pioglitazone, was approved in 1999 to lower glycemic levels in adults with Type-2 diabetes. The drug is an insulin sensitizer which helps the body better use insulin. Type-2 diabetes is caused when the body no longer responds to insulin and can result in overeating and lack of exercise. Bladder cancer is the sixth most common cancer in the U.S.. According to the U.S. National Cancer Institute, in 2010, it was estimated that 70,530 men and women were diagnosed and 14,680 died. Each year in the U.S., more than 52,000 men and 18,000 women are diagnosed.

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