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HIV Drug Associated with Deadly Skin Reactions | cialis online

HIV Drug Associated with Deadly Skin Reactions

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The maker of the HIV drug Intelence (etravirine) has warned that it has been associated with severe, and sometimes life-threatening skin reactions, which may be accompanied by liver failure.  According to a letter to health care providers from Johnson & Johnson’s Tibotec division,  those reactions include Stevens-Johnson syndrome and   toxic epidermal necrolysis.

Stevens-Johnson syndrome is a hypersensitivity complex affecting the skin and the mucous membrane.  The disorder causes blistering of mucous membranes, typically in the mouth, eyes, and vagina, and patchy areas of rash.  Toxic epidermal necrolysis presents with a similar blistering of mucous membranes. However, in addition to blistering, the entire epidermis peels off in sheets from large areas of the body. Both disorders can be life threatening.

According to,  toxic epidermal necrolysis has killed one patient and injured another since Intelence was approved.  Another patient reported a hypersensitivity reaction accompanied by liver failure.  According to Tibotec, in clinical trails 1.3 percent of people taking Intelence developed moderate to severe rashes, compared with 0.2 percent of people who received a placebo in those trials.

According to the letter, the hypersensitivity  reactions associated with Intelence are characterized by rash, flulike symptoms and sometimes organ problems, including liver failure. Rashes typically appeared within the first six weeks of therapy with Intelence. If the rash becomes severe, the prescribing information warns, individuals using the drug should contact their health care providers immediately to discuss possibly stopping Intelence. According to  Tibotec, the existing Warning and Precaution regarding Severe Skin Reactions has been strengthened to reflect the reports of skin reactions.

Intelence was approved by the Food & Drug Administration (FDA) in 2008.  It is a non-nucleoside reverse transcriptase inhibitor, and is used to treat people who have become resistant to other HIV medications.

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