Buy this domain.

Health Canada Follows the FDA in Warning of Potentially Fatal Interaction between Slow-Release Painkillers and Alcohol | cialis online

Health Canada Follows the FDA in Warning of Potentially Fatal Interaction between Slow-Release Painkillers and Alcohol

AddThis Social Bookmark Button

Health Canada’s Therapeutic Products Directorate (TPD) is the Canadian federal authority that regulates pharmaceutical drugs and medical devices for human use.

The agency is the equivalent of the U.S. Food and Drug Administration (FDA). Both have now issued similar warnings concerning the potentially deadly interaction between one particular slow-release “opioid” painkiller, Palladone XL, and alcohol in any amount.

The two agencies have taken different approaches to the problem, however. On July 13, the FDA asked Palladone’s maker, Purdue Pharma L.P., to withdrawn the drug from the market in the United States. No mention was made in the FDA releases of other opioids posing the same risk when combined with alcohol. Purdue Pharma voluntarily agreed to suspend sales of Palladone in the United States.

In ordering the withdrawal of Palladone, the FDA released a series of announcements including an ALERT (, a PUBLIC HEALTH ADVISORY (, QUESTIONS AND ANSWERS (, and an ALERT FOR HEALTHCARE PROFESSIONALS (

Taking a different approach, the newly issued advisory by Health Canada does not order the recall of Palladone. Instead, the Canadian warning of the potentially fatal interaction extends to all opioids based on the premise that “there may be a possibility that these products could react in the same way when taken with alcohol.”

Health Canada has requested the manufacturers of other similar drugs to provide data on their products’ interaction with alcohol within six months.

Palladone XL has not been shipped to Canada since December 2004 and there are currently no supplies of the drug on the Canadian market.

The danger posed by the combination of any amount of alcohol and Palladone XL comes about because the slow-release form of hydromorphone contained in the drug can be overridden by the introduction of alcohol. This can cause an effect known as “dose dumping” where the hydromorphone is released quickly into the blood in dangerous levels rather than over the intended 24-hour period.

Slow-release drugs are also marketed as extended release, time-release, controlled release, and controlled delivery and often carry SR, XR, XL, SRC, and SRT after the brand name. Other slow-release opioids currently on the market in Canada include: Hydromorph Contin (hydromorphone); Kadian SRC (morphine sulfate); M.O.S. SR (morphine hydrochloride); M-Elson (morphine sulfate); MS Contin SRT (morphine sulfate); Oxycontin SRT (oxycodone); PMS-Morphine Sulfate SR (morphine sulfate); Ratio-Morphine SR (morphine sulfate); Roxanol SR (morphine sulfate); and Zomorph (morphine sulfate).

It remains unclear whether alcohol may also affect the slow-release mechanisms in these other opioids thereby causing “dose dumping” similar to what has been found with Palladone XL. Obviously, anyone taking any of these powerful narcotic drugs should not combine them with alcohol under any circumstances and especially until further data regarding the interaction is forthcoming.

« »

Comments are closed.




Defective Johnson & Johnson Depuy ASR Hip Implants

The Johnson & Johnson Depuy ASR Hip Implant is suppose to last 15 years, but can fail in only a few years after surgery. Victims with faulty hip implants endure excruciating pain, pain in the groin, death of tissue in the hip joint and loss of surrounding bone. GET ALL THE FACTS NOW! CLICK HERE!

CAT Scans Radiation Exposure

If you had a CT or CAT scan and now have a band of missing hair, skin reddening or any other problems possibly related to a radiation overdose, you may have been exposed to much radiation due to incorrect settings on these machines. CONTACT US TODAY!

Water Contamination From Fracking

Hydraulic Fracturing of Fracking a way to extract natural gas from shale is contaminating water supplies across the country. Get the facts to keep your drinking water safe for your family.

Overexposure to PCBs

Many people unknowingly have been exposed to high levels of PCBs. Recently 3 schools in NY City were found to have dangerous levels of PCBs throughout. Many workers for Monsanto, General Electric, and Westinghouse were exposed to high levels of PCBs. PCBs are a dangerous toxic substance that doesn't break down easily and can cause chloracne, bleeding and neurological disorders, liver damage, spontaneous abortions, malformed babies, cancer, and death. GET THE FACTS!
Overexposure to

Great Photography

Tallis Photo, the number one photographer for great corporate, wedding, and special occasion photos. CONTACT US TODAY!

Poligrip Lawsuit

Super Poligrip or Fixodent May Cause Nerve Damage. 800-LAW-INFO

Personal Injury Lawyer Nassau County

If you or someone you love was injured CONTACT US TODAY!

Nursing Home Blog

When a loved one is abused at a nursing home, it is time to take action. STOP nursing home abuse!

Car Accident Lawyer Nassau County

If you or someone you love was injured in an auto accident CONTACT US TODAY!

Suffolk County Auto Accident Lawyer

If you or someone you love was injured in an auto accident in Suffolk County, NY CONTACT US TODAY!

Don't Be Denied Veterans Benefits

If you or someone you love was denied veterans benefits CONTACT US TODAY!

Oil Rig Spills Lawyer

Oil Rig Spills harm the environment and cause heavy losses to coastal game and fishing industries, as well as a loss of waterway usage, resulting in a loss of income to individuals and businesses, and a loss of beach front usage. Don't let a spill cause you harm, CONTACT US TODAY!

Whistle Blower

Stand up and say what you think is right. See something, say something.