Buy this domain.

Doctors Warned of Fungal Infections With Simponi | cialis online

Doctors Warned of Fungal Infections With Simponi

AddThis Social Bookmark Button

A new TNF-alpha blocker called  Simponi may  cause severe and potentially fatal fungal infections, according to a  new “Dear Healthcare Professional” letter recently issued by Centocor Ortho Biotech, Inc.  Simponi was only approved in April as a treatment for adult patients with: moderate to severe rheumatoid arthritis in combination with methotrexate, psoriatic arthritis (either alone or in combination with methotrexate), and ankylosing spondylitis.

In the letter, Centocor Ortho  warns that invasive fungal infections are not consistently recognized in patients taking  TNF-alpha blockers.  This has resulted in delays in appropriate antifungal treatment, sometimes even resulting in death.  For patients who reside or travel in regions where mycoses are endemic (eg, Ohio and Mississippi River valleys and southwestern United States), invasive fungal infection should be suspected if they develop a serious systemic illness,  the letter  warns.

Centocor Ortho’s letter also advises doctors to  carefully review  Simponi’s prescribing information, which includes  important information about the risk of serious infections including TB and invasive fungal infections, such as histoplasmosis, in a Boxed Warning.  When making a decision to use Simponi, doctors must balance the potential benefits with the potential risks of therapy based upon a patient’s individual need, the letter says.

Doctors should encourage patients to report signs of infection and be closely monitored during and after treatment with Simponi and other TNF-alpha blockers for the development of invasive fungal infection. Signs and symptoms of  such disorders include fever, malaise, weight loss, sweats, cough and dyspnea,  pulmonary infiltrates on X-ray or serious systemic illness.   TNF-alpha blockers should be discontinued in patients who develop such symptoms, and they should undergo a complete diagnostic workup.  Once an infection has cleared, use of Simponi and other TNF-alpha blockers may be restarted based on a reevaluation of risks and benefits, th letter says.

TNF-alpha blockers work by suppressing the immune system.  Other drugs in this class include Humira, Cimzia, Enbrel, and Remicade. It has long been known that people taking TNF-alpha blockers run a risk of developing opportunistic infections, including  histoplasmosis, an infection caused by the fungus Histoplasma capsulatum.    Last fall, the Food & Drug Administration ordered the makers of TNF-alpha blockers to strengthen the existing warnings about opportunistic fungal infections linked to the drugs.

« »

Leave a Reply

You must be logged in to post a comment.




Defective Johnson & Johnson Depuy ASR Hip Implants

The Johnson & Johnson Depuy ASR Hip Implant is suppose to last 15 years, but can fail in only a few years after surgery. Victims with faulty hip implants endure excruciating pain, pain in the groin, death of tissue in the hip joint and loss of surrounding bone. GET ALL THE FACTS NOW! CLICK HERE!

CAT Scans Radiation Exposure

If you had a CT or CAT scan and now have a band of missing hair, skin reddening or any other problems possibly related to a radiation overdose, you may have been exposed to much radiation due to incorrect settings on these machines. CONTACT US TODAY!

Water Contamination From Fracking

Hydraulic Fracturing of Fracking a way to extract natural gas from shale is contaminating water supplies across the country. Get the facts to keep your drinking water safe for your family.

Overexposure to PCBs

Many people unknowingly have been exposed to high levels of PCBs. Recently 3 schools in NY City were found to have dangerous levels of PCBs throughout. Many workers for Monsanto, General Electric, and Westinghouse were exposed to high levels of PCBs. PCBs are a dangerous toxic substance that doesn't break down easily and can cause chloracne, bleeding and neurological disorders, liver damage, spontaneous abortions, malformed babies, cancer, and death. GET THE FACTS!
Overexposure to

Great Photography

Tallis Photo, the number one photographer for great corporate, wedding, and special occasion photos. CONTACT US TODAY!

Poligrip Lawsuit

Super Poligrip or Fixodent May Cause Nerve Damage. 800-LAW-INFO

Personal Injury Lawyer Nassau County

If you or someone you love was injured CONTACT US TODAY!

Nursing Home Blog

When a loved one is abused at a nursing home, it is time to take action. STOP nursing home abuse!

Car Accident Lawyer Nassau County

If you or someone you love was injured in an auto accident CONTACT US TODAY!

Suffolk County Auto Accident Lawyer

If you or someone you love was injured in an auto accident in Suffolk County, NY CONTACT US TODAY!

Don't Be Denied Veterans Benefits

If you or someone you love was denied veterans benefits CONTACT US TODAY!

Oil Rig Spills Lawyer

Oil Rig Spills harm the environment and cause heavy losses to coastal game and fishing industries, as well as a loss of waterway usage, resulting in a loss of income to individuals and businesses, and a loss of beach front usage. Don't let a spill cause you harm, CONTACT US TODAY!

Whistle Blower

Stand up and say what you think is right. See something, say something.