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Rituxan Study Finds Link to Fatal Brain Infection | cialis online

Rituxan Study Finds Link to Fatal Brain Infection

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Rituxan, the most widely used drug to treat lymphoma, has been linked to progressive multifocal leukoencephalitis (PML), according to the findings of a new study.

PML is a viral infection that affects the white matter of the brain.  Patients with PML exhibit neurological symptoms like confusion, dizziness or loss of balance, difficulty talking or walking, and vision problems. PML gets worse over time, and is usually fatal. There is no treatment or cure for the disease.  It is often associated with drugs that suppress the immune system. 

The new Rituxan PML study, which is detailed in Science Daily, was conducted by researchers with the Northwestern University Feinberg School of Medicine RADAR project.  RADAR ((Research on Adverse Drug Events and Reports) is an international consortium of physicians that collaborate to identify adverse reactions to medications and devices.

According to the study, 57 Rituxan  patients developed PML between 1997 and 2008. The head of  the RADAR project told Science Daily that considering the study’s findings, there is a  need for caution in prescribing Rituxan.

“The drug has tremendous usefulness in lymphoma, but as its use expands to diseases that are not cancer, we might have to reconsider the risk benefit,” Charles Bennett, M.D said. “Some cancer patients take this drug chronically for non-fatal chronic leukemia where the risk-benefit calculations differ from lymphoma.”

According to Science Daily, in  addition to being a treatment for lymphoma,  Rituxan is also approved as a therapy for rheumatoid arthritis, and is used off-label to treat multiple sclerosis, lupus erythematosus and autoimmune anemias.

According to Science Daily,  the 57 Rituxan PML patients identified in  the RADAR study were using the drug as a treatment for anemia, rheumatoid arthritis or lymphoma.  On average, they died just two months after being diagnosed.  While it is known that a small number of lymphoma patients will develop PML  regardless of the treatment they undergo, it is not typically seen in anemia or arthritis patients, Science Daily said.

Last September, the labeling for Rituxan was updated to reflect its association with PML. At the time, the Food & Drug Administration (FDA) said that at least two patients given Rituxan as a treatment for systemic lupus erythematosus had died from PML.

Bennett told Science Daily that the next step in RADAR’s research will be to determine what risk factors might be linked to Rituxan-associated PML.

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