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Report: Drugmaker Tried to Silence Another Avandia Critic

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A doctor in Maryland has claimed that the maker of Avandia tried to shut her up when she criticized the controversial drug.  Dr. Mary Money, a Hagerstown internist, recently spoke with the  The Wall Street Journal about her experience with Glaxo after she and a colleague voiced concerns about Avandia in 2000

According to Dr. Money, she and another doctor, Stephen Lippman, at Washington County Hospital in Hagerstown, met with representatives of SmithKlineBeecham, and presented data on 85 of their  Avandia patients.  According to The Wall Street Journal, more than half of the patients had significant edema, or swelling, and about half of that group also had high pulmonary pressure and shortness of breath. Three had been hospitalized for congestive heart failure.

Dr. Money told the Journal that the representatives from the drug maker dismissed her concerns.  What’s more, the next month, the drug maker wrote to the hospital’s chief of staff in an attempt to force Dr. Money to stop talking about her worries with other doctors.

Fortunately, Dr. Money’s superiors chose to trust her judgment, and ignored SmithKlineBeecham’s letter.    According to the Journal, Dr. Money has continued to discourage the use of Avandia when speaking to colleagues.

Avandia’s cardiovascular problems have been the subject of concern since May 2007, when an analysis of 42 clinical trails published by the Cleveland Clinic showed that patients taking the drug had a 43-percent higher risk of having a heart attack.  That summer, GlaxoSmithKline, the maker of Avandia and the Food & Drug Administration (FDA) came under fire for an apparent failure to warn the public about the cardiac risks associated with Avandia.

Last year, we reported that a Senate Finance Committee was investigating whether or not the drug comany tried to silence Dr. John Buse, a diabetes expert and professor of medicine at the University of North Carolina in Chapel Hill. In 1999, Dr. Buse began expressing concerns about the cardiovascular risks of Avandia.   The summer before that report was published, the Senate committee heard testimony from Dr.  Buse, who said he felt pressured by the drug’s maker, SmithKlineBeecham (now part of GlaxoSmithKline) to sign a clarifying statement drafted by the company that downplayed his concerns.  During his testimony, Dr. Buse described name-calling and what he said was the veiled threat of a lawsuit by a high-ranking drug company executive after he had criticized Avandia at a medical meeting.  Dr. Buse also testified that the drug complained about him to his supervisors at the University of North Carolina.

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