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Another Celebrex Study Finds Higher Heart Attack, Stroke Risk | cialis online

Another Celebrex Study Finds Higher Heart Attack, Stroke Risk

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A new Celebrex study has linked high doses of the drug to a higher risk of stroke and heart attacks in patients already at a high risk for heart problems.

The Celebrex study, sponsored by the National Cancer Institute, consisted of a combined analysis of six studies of the Pfizer pain drug, and included 7,950 patients. The researchers found that patients receiving the highest dose of Celebrex of 400 milligrams twice daily had a nearly three times higher risk of heart attacks and strokes than patients not taking the drug. Patients taking a lower dose of Celebrex, 400 milligrams once daily, had a 10% higher risk of a cardiovascular event. This risk was not affected by daily aspirin therapy.

The study did not look at patients taking a once-daily, 200-milligram dose of Celebrex, which represents the way the drug is most commonly prescribed. Dr. Steven Nissen of the Cleveland Clinic, who has a study on lower doses underway, told Reuters that the conclusions that could be based on this latest Celebrex study were limited. “There aren’t long-term randomized placebo-controlled trials for that dose, The only way we’re ever going to answer these questions is with good randomized prospective data,” he said. “We’ll tell it like it is when the data is in.”

The lead researcher on this latest Celebrex study, Dr. Scott Solomon, said the findings do indicate that doctors should use caution in prescribing the prescription pain reliever, and should use low doses when they use Celebrex to treat people at a high risk for heart problems.

Celebrex belongs to a class of drugs known as COX-2 inhibitors and is the only such drug still on the market in the US. Blocking the COX-2 enzyme impedes the production of the chemical messengers (prostaglandins) that cause the pain and swelling of arthritis inflammation. COX-2 inhibitors have been linked to an increased risk of blood clots, heart attacks and strokes. In 2004, another COX-2 inhibitor, Vioxx was removed from the market after studies linked it to more than 27,000 heart attacks or sudden cardiac deaths in the U.S. from 1999 through 2003. Another COX-2 inhibitor called Bextra was also pulled from the US market due to safety concerns.

Celebrex carries the Food and Drug Administration’s strictest “black-box” warning on its drug label, stating that it may cause an increased risk of serious cardiovascular events such as heart attacks and strokes.

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