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Senator Wants Answers on Vytorin Study | 24-7-news.com cialis online

Senator Wants Answers on Vytorin Study

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Emails are rasing more questions about an important Vytorin study that was delayed for more than a year. Now, Senator Charles Grassley (R-Iowa) has sent a letter to Merck and Schering-Plough seeking more explanation on the delay in releasing the ENHANCE study, which showed Vytorin to be no more effective than cheaper studies in preventing clogged arteries. Sen. Grassley’s letter said the emails, supplied by the companies, indicated Schering-Plough and Merck may have delayed for more than a year releasing results ENHANCE, for “marketing purposes.” Sen. Grassley also asked for details about payments made to researchers and doctors who promoted the Vytorin.

According to The Wall Street Journal, Sen. Grassley, a member of the Senate Finance Committee, is among several lawmakers probing whether the companies deliberately withheld negative information to protect sales of Vytorin and a sister drug Zetia. The companies have denied that and said they were trying to resolve issues with flaws in the data.

The incriminating emails between company executives and the ENHANCE study’s lead researcher, John P. Kastelein of Academic Medical Center, Amsterdam, indicate that Kastelein was upset with the companies decision to withhold ENHANCE from last November’s America Heart Association meeting. Excerpts of the emails were released in Sen. Grassley’s letter. “If this is true, [Schering-Plough] must have taken this decision without even the semblance of decency to consult me,” Kastelein wrote in an email sent July 6. “I can tell you if this is the case, our collaboration is over. This starts smelling like extending the publication [of the study] for no other [than] political reasons and I cannot live with that.”

Vytorin is a combination of cholesterol-lowering Zetia and the statin Zocor. Statins like Zocor reduce the amount of cholesterol produced by the liver, while Zetia lessens the amount of cholesterol in food that is absorbed in the intestines. High cholesterol levels put a person at risk of developing clogged arteries – a major risk factor for heart attacks and strokes. But ENHANCE, which was released on January 14, showed that Vytorin was ineffective in preventing clogged arteries, and might actually increase plaque in some users.Over the weekend, the full ENHANCE study was vetted during the annual meeting of the American College of Cardiology. A panel of four doctors concluded that Vytorin should be used only as a last resort, considering that the expensive drug did not provide any added benefits. “Our strongest recommendation is that people need to go back to statins,” said panel member Dr. Harlan Krumhotz.

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